Nonlinear Mixed Effects Models in Population PK/PD, Estimation Routines
Add CWRES
NPDE calculation for nlmixr2
Add table information to nlmixr2 fit object without tables
Control options for the agq estimation method
Assert that this is a nlmixr2 fit object
Assert that this is a nlmixr2 fit data object
Control for bobyqa estimation method in nlmixr2
Cox Box, Yeo Johnson and inverse transformation
Generalized Cholesky Matrix Decomposition
Adds a package to the nlmixr2's $sessioninfo inside the fit
Get the adaptive Gauss-Hermite quadrature points and weights
Augment Prediction for Ipred Model
Collect warnings and just warn once.
Identify Differences Between Standard and New Objects but used in rxUi...
Deparse finalize a control or related object into a language object
This downgrades the UI for any of the zero etas in the model
This function process the data for use in focei
Initialize S3 methods
Adjust covariance matrix based on scaling parameters
Finalizes output list
Frees nlm environment
Preprocess Covariates needed (or other data items)
Get the least prediction simulation information for VPC
Update model to have final parameter estimates for piping and save ori...
Allows external methods (like those in nlmixr2) to assign object name
A surrogate function for nlme to call for ode solving
A surrogate function for nlm to call for ode solving
A surrogate function for nlminb to call for ode solving
Returns the data currently setup to run nls
A surrogate function for nls to call for ode solving
Internal nls functions for minpack.lm
A surrogate function for optim to call for ode solving
This literally fixes parameters in the model
Setup a nonlinear system for optimization
Preprocess the zero omegas
Preprocess the zero omegas
Get the DV transformation
Drop mu referenced etas and covariates
This is an internal function for modifying the UI to apply mu2 referen...
This is an internal function for replacing the ui with original model ...
Control options for the foce estimation method
Control Options for FOCEi
Fit/Evaluate FOCEi
Control options for the FO estimation method
Control options foir the FOI estimation method
Method for getting simulation rxode2 classic models based on fits
Get valid nlmixr control object
Control options for the Laplace estimation method
Control for lbfgsb3c estimation method in nlmixr2
Control for n1qn1 estimation method in nlmixr2
Control for newuoa estimation method in nlmixr2
nlmixr2 defaults controls for nlm
nlmixr2 nlminb defaults
nlmixr2 fits population PK and PKPD non-linear mixed effects models.
Show all the current estimation methods
Augmented Prediction for nlmixr2 fit
Create nlmixr output from the UI
Generic for nlmixr2 estimation methods
Try to fix a nlmixr2 fit
Get the optimal forward difference interval by Gill83 method
Create a gradient function based on gill numerical differences
Calculate Hessian
Transform the estimated value to %CV for IOV
Messages the nlmixr2 logo...
Control Values for nlme Fit with extra options for nlmixr
Print x using the message facility
Validate nlmixr2
Display nlmixr2's version
Add objective function data frame to the current objective function
Manually add time to a nlmixr2 object
nlmixrCbind
Clone nlmixr environment
Update the nlmixr2 object with new fit information
Time a part of a nlmixr operation and add to nlmixr object
nlmixr2 defaults controls for nls
This is a S3 method for getting the distribution lines for a base rxod...
C++ implementation of Matrix's nearPD
Get an item from a nlmixr core object
Get control object from fit
Get an item from a nlmixr2FitData object
Get the estimation model for a fit object depending on the object type
Method for getting focei compatible control object from nlmixr object
Get the ipred model for a fit object depending on the object type
Get the pred-only model for a fit depending on the object type
Get an option for the estimation method
Handle the control object
Handle Model Object
Set if the nlmixr2 object will return a compressed ui
Nelder-Mead simplex search
Respect suppress messages for nlmixr2 C functions
Return the objective function
nlmixr2 optim defaults
Control options for the posthoc estimation method
Return a list of all pre-processing hooks
This adds a pre-processing hook to nlmixr2est
Remove the hook from nlmixr2est
Print an SAEM model fit summary
Objects exported from other packages
Extract residuals from the FOCEI fit
Remove an eta from the model
This is a S3 method for getting the distribution lines for a base rxod...
This is a S3 method for getting the distribution lines for a base rxod...
This is a S3 method for getting the distribution lines for a base rxod...
Control Options for SAEM
Set the covariance type based on prior calculated covariances
Set/get Objective function type for a nlmixr2 object
Return the square root of general square matrix A
Print an SAEM model fit summary
Output table/data.frame options
Control for uobyqa estimation method in nlmixr2
Name the data and compartments
VPC simulation
Expand a VPC simulation
Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).