Personalized Repeated Measurement Design for Phase I Clinical Trials
Suggest the input eff.structure of function SimPRMD with selected ...
Compute the summary statistics of efficacy measure with specified para...
Generate the nTTP dictionary
Generate the mean nTTP score and the probability of observing DLT for ...
Display patient records
Plot nTTP and efficacy boxplots of a RunPRMD object
Plots of a SimPRMD object
Displays a useful description of a summary.RunPRMD object
Displays a useful description of a summary.SimPRMD object
Implement a Multi-Stage Phase I Dose-Finding Design to recommend dosag...
Simulation for a Multi-Stage Phase I Dose-Finding Design
Summary a RunPRMD object
Summary a SimPRMD object
Implements Bayesian phase I repeated measurement design that accounts for multidimensional toxicity endpoints and longitudinal efficacy measure from multiple treatment cycles. The package provides flags to fit a variety of model-based phase I design, including 1 stage models with or without individualized dose modification, 3-stage models with or without individualized dose modification, etc. Functions are provided to recommend dosage selection based on the data collected in the available patient cohorts and to simulate trial characteristics given design parameters. Yin, Jun, et al. (2017) <doi:10.1002/sim.7134>.