Repeated Measurement Design for Phase I Clinical Trial
Toxicity Probability Matrices Generation for Trial Simulation
Create prior for the phase 1 dose-finding model
plot nTTP Toxicity-based in cycle 1 for all doses.
Toxicity-based Dose estimation for the next patient cohort.
Interactive Implementation for an Adaptive, Multi-Stage Phase I Dose-F...
Simulate trial characters of the phase I dose-finding design.
Simulation for an Adaptive, Multi-Stage Phase I Dose-Finding Design
Probability matrix for toxicity
Compute the nTTP score baed on the observed toxicity.
Implements our Bayesian phase I repeated measurement design that accounts for multidimensional toxicity endpoints from multiple treatment cycles. The package also provides a novel design to account for both multidimensional toxicity endpoints and early-stage efficacy endpoints in the phase I design. For both designs, functions are provided to recommend the next dosage selection based on the data collected in the available patient cohorts and to simulate trial characteristics given design parameters. Yin, Jun, et al. (2017) <doi:10.1002/sim.7134>.