Model Fitting and Simulation for Drug Release Kinetics and PK/PD
First-Order Drug Release Kinetic Model
Higuchi Drug Release Kinetic Model
Hixson-Crowell Drug Release Kinetic Model
Korsmeyer-Peppas Drug Release Kinetic Model
One-Compartment IV Bolus Pharmacokinetic Model (Linear)
Weibull Drug Release Kinetic Model
Zero-Order Drug Release Kinetic Model
Lethal Dose 50 (LD50) Pharmacodynamic Model
4PL Logistic Dose-Response Model (Emax/Imax)
5PL Logistic Dose-Response Model (Emax/Imax, Asymmetric)
Michaelis-Menten Kinetics (Nonlinear Form) with Inhibition Comparison
Michaelis-Menten Kinetics (Linear Form) with Inhibition Comparison
Non-Compartmental Analysis (NCA) of Plasma Concentration-Time Data (No...
Non-Compartmental Analysis (NCA) of Plasma Concentration-Time Data (Li...
One-Compartment IV Bolus Pharmacokinetic Model (Nonlinear)
One-Compartment Oral Pharmacokinetic Model (Nonlinear, First-Order Abs...
One-Compartment Oral Pharmacokinetic Model (Linear, First-Order Absorp...
Sigmoid Emax (Stimulatory Hill Model) for Dose-Response Analysis
Sigmoid Imax (Inhibitory Hill Model) for Dose-Response Analysis
Toxic Dose 50 (TD50) Pharmacodynamic Model
Two-Compartment IV Bolus Pharmacokinetic Model (Nonlinear)
Two-Compartment IV Bolus Pharmacokinetic Model (Linear)
Provides a comprehensive framework for model fitting and simulation of drug release kinetics, pharmacokinetics (PK), and pharmacodynamics (PD). The package implements widely used mechanistic and empirical models for in vitro drug release, including zero-order, first-order, Higuchi, Korsmeyer-Peppas, Hixson-Crowell, and Weibull models. Pharmacokinetic functionality includes linear and nonlinear functions for one- and two-compartment models for intravenous bolus and oral administration, Michaelis-Menten kinetics, and non-compartmental analysis (NCA). Pharmacodynamic and dose-response modeling is supported through Emax-based models, including stimulatory (sigmoid Emax) and inhibitory (sigmoid Imax) Hill models, four- and five-parameter logistic models, as well as median toxic dose (TD50) and lethal dose (LD50) models. The package is intended to support parameter estimation, simulation, and model comparison in pharmaceutical research, drug development, and pharmacometrics education. For more details, see Gabrielsson & Weiner (2000) <ISBN:9186274929>, Holford & Sheiner (1981) <doi:10.2165/00003088-198106060-00002>, and Manlapaz (2025) <doi:10.32614/CRAN.package.adsoRptionCMF>.