Pharmacokinetics in R
Calculate Area Under the Curve (AUC) and Area Under the first Moment C...
Internal Functions
Choose best fit slope for the log(y) and x regression by the criteria ...
Combine XPT files
Convert intermeidate NCA result to adequate unit.
Forest plot to compare NCA results
Noncompartmental Analysis for an Individual
Calculate interval AUC
Interpolate y value
Area Under the Curve(AUC) and Area Under the first Moment Curve(AUMC) ...
Load EX and PC domain files in folders
Area Under the Curve(AUC) and Area Under the first Moment Curve(AUMC) ...
Noncompartmental analysis for a dataset with multiple subjects
NCA of SDTM data for single subject
NCA output to pdf file
Pharmacokinetics in R
Plot best fit slope
Plot concentration vs. time curve for individuals and collectively.
Read EX domain files
Read PC domain files
Do NCA for review
Round Half Away from Zero
NCA Report Configuation Table
NCA output to rtf file
Get the Slope of regression log(y) ~ x
Simplest NCA
Internal Functions
Table output NCA
Text output of NCA for one subject
Disply CDISC standard units and multiplied factor of NCA results
Internal Functions
Conduct a noncompartmental analysis as closely as possible to the most widely used commercial software. Some features are 1) CDISC SDTM terms 2) Automatic slope selection with the same criterion of WinNonlin(R) 3) Supporting both 'linear-up linear-down' and 'linear-up log-down' method 4) Interval(partial) AUCs with 'linear' or 'log' interpolation method * Reference: Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016. (ISBN:9198299107).