Noncompartmental Pharmacokinetic Analysis by qPharmetra
Impute Concentrations Below the Limit of Quantitation
Correct Concentrations for Time Deviations
Calculate Lambda_z and Elimination Half-life
Create File Name for Regression Plots
Interpolate Concentrations
Estimate Lagging and Leading Times and Concentrations
Calculate Cmax and Tmax
Calculate NCA Parameters
Calculate Lambda_z Parameters
Check qpNCA function arguments for validity
Correct Missing Concentration
Plot Regression Curves
Perform Non-compartmental Analysis
Tabulate Corrections
Create Title for Regression Plots
Calculate Area Under the Curve Using Trapezoids
Calculate Area Under the Moment Curve Using Trapezoids
Computes noncompartmental pharmacokinetic parameters for drug concentration profiles. For each profile, data imputations and adjustments are made as necessary and basic parameters are estimated. Supports single dose, multi-dose, and multi-subject data. Supports steady-state calculations and various routes of drug administration. See ?qpNCA and vignettes. Methodology follows Rowland and Tozer (2011, ISBN:978-0-683-07404-8), Gabrielsson and Weiner (1997, ISBN:978-91-9765-100-4), and Gibaldi and Perrier (1982, ISBN:978-0824710422).