qtl2pleio1.4.3 package

Testing Pleiotropy in Multiparental Populations

add_pmap

Add physical map contents to tibble

boot_pvl

Perform bootstrap sampling and calculate test statistic for each boots...

calc_Bhat

Calculate estimated allele effects, B matrix

calc_covs

Calculate Vg and Ve from d-variate phenotype and kinship

calc_invsqrt_mat

Calculate matrix inverse square root for a covariance matrix

calc_lrt_tib

Calculate a likelihood ratio test statistic from the output of scan_pv...

calc_profile_lods

Calculate profile lods for all traits

calc_Sigma

Calculate the phenotypes covariance matrix Sigma

calc_sqrt_mat

Calculate matrix square root for a covariance matrix

check_identical

Check whether a vector, x, has all its entries equal to its first entr...

check_missingness

Check for missingness in phenotypes or covariates

convert_to_scan1_output

Convert scan_multi_oneqtl output of qtl2::scan1 output

find_pleio_peak_tib

Find the marker index corresponding to the peak of the pleiotropy trac...

fit1_pvl

Fit a model for a specified d-tuple of markers

get_effects

Extract founder allele effects at a single marker from output of qtl2:...

make_id2keep

Identify shared subject ids among all inputs: covariates, allele proba...

pipe

Pipe operator

plot_pvl

Plot tidied results of a pvl scan

prep_mytab

Prepare mytab object for use within scan_pvl R code

prep_X_list

Create a list of component X matrices for input to stagger_mats, to ul...

process_inputs

Process inputs to scan functions

qtl2pleio

qtl2pleio.

rcpp_calc_Bhat

Estimate allele effects matrix, B hat, with Rcpp functions

rcpp_calc_Bhat2

Estimate allele effects matrix, B hat, with Rcpp functions

rcpp_log_dmvnorm2

Calculate log likelihood for a multivariate normal

scan_multi_onechr

Perform multivariate, one-QTL model fitting for markers on one chromos...

scan_multi_oneqtl

Perform multivariate, one-QTL model fitting for markers on all chromos...

scan_multi_oneqtl_perm

Permute the phenotypes matrix and then scan the genome. Record the gen...

scan_pvl

Perform model fitting for all ordered pairs of markers in a genomic re...

sim1

Simulate a single multivariate data set consisting of n subjects and d...

subset_input

Subset an input object - allele probabilities array or phenotypes matr...

subset_kinship

Subset a kinship matrix to include only those subjects present in all ...

We implement an adaptation of Jiang & Zeng's (1995) <https://www.genetics.org/content/140/3/1111> likelihood ratio test for testing the null hypothesis of pleiotropy against the alternative hypothesis, two separate quantitative trait loci. The test differs from that in Jiang & Zeng (1995) <https://www.genetics.org/content/140/3/1111> and that in Tian et al. (2016) <doi:10.1534/genetics.115.183624> in that our test accommodates multiparental populations.

  • Maintainer: Frederick J Boehm
  • License: MIT + file LICENSE
  • Last published: 2020-12-02