generate_data_single function

Generate data for a single group

generate_data_single(pars_group, strategy_fun = NULL, distr_pars_ref = NULL)

Arguments

• pars_group: A simul_pars object as generated by set_simul_pars(). It specifies the simulation parameters of the given group.

• strategy_fun: Function implementing trajectories after the intercurrent event (ICE). Must be one of getStrategies(). See getStrategies() for details. If NULL then post-ICE outcomes are untouched.

• distr_pars_ref: Optional. Named list containing the simulation parameters of the reference arm. It contains the following elements:

  • mu: Numeric vector indicating the mean outcome trajectory assuming no ICEs. It should include the outcome at baseline.
  • sigma Covariance matrix of the outcome trajectory assuming no ICEs. If NULL, then these parameters are inherited from pars_group.

Returns

A data.frame containing the simulated data. It includes the following variables:

• id: Factor variable that specifies the id of each subject.
• visit: Factor variable that specifies the visit of each assessment. Visit 0 denotes the baseline visit.
• group: Factor variable that specifies which treatment group each subject belongs to.
• outcome_bl: Numeric variable that specifies the baseline outcome.
• outcome_noICE: Numeric variable that specifies the longitudinal outcome assuming no ICEs.
• ind_ice1: Binary variable that takes value 1 if the corresponding visit is affected by ICE1 and 0 otherwise.
• dropout_ice1: Binary variable that takes value 1 if the corresponding visit is affected by the drop-out following ICE1 and 0 otherwise.
• ind_ice2: Binary variable that takes value 1 if the corresponding visit is affected by ICE2.
• outcome: Numeric variable that specifies the longitudinal outcome including ICE1, ICE2 and the intermittent missing values.

See Also

simulate_data().