Reference Limit Estimation Using Routine Laboratory Data
Plausible Rounding
Bowley skewness
Confidence intervals of estimated reference limits
Removal of pathological values
Colors and text modules to interprete deviations from given target val...
Lognormal distribution model
Tolerance intervals of estimated and target limits
Reference limits (main function)
Histogram with density plots and reference limits
Quantile-Quantile plot of truncated laboratory results
Uses an indirect method based on truncated quantile-quantile plots to estimate reference limits from routine laboratory data: Georg Hoffmann and colleagues (2024) <doi: 10.3390/jcm13154397>. The principle of the method was developed by Robert G Hoffmann (1963) <doi:10.1001/jama.1963.03060110068020> and modified by Georg Hoffmann and colleagues (2015) <doi:10.1515/labmed-2015-0104>, and Frank Klawonn and colleagues (2020) <doi:10.1515/labmed-2020-0005>, (2022) <doi:10.1007/978-3-031-15509-3_31>.