etTrans function

Event translation for rxode2

etTrans(
  inData,
  obj,
  addCmt = FALSE,
  dropUnits = FALSE,
  allTimeVar = FALSE,
  keepDosingOnly = FALSE,
  combineDvid = NULL,
  keep = character(0),
  addlKeepsCov = FALSE,
  addlDropSs = TRUE,
  ssAtDoseTime = TRUE,
  iCov = NULL
)

Arguments

• inData: Data frame to translate

• obj: object where model variables can be extracted from

• addCmt: Add compartment to data frame (default FALSE).

• dropUnits: Boolean to drop the units (default FALSE).

• allTimeVar: Treat all covariates as if they were time-varying

• keepDosingOnly: keep the individuals who only have dosing records and any trailing dosing records after the last observation.

• combineDvid: is a boolean indicating if rxode2 will use DVID on observation records to change the cmt value; Useful for multiple-endpoint nlmixr models. By default this is determined by option("rxode2.combine.dvid") and if the option has not been set, this is TRUE. This typically does not affect rxode2 simulations.

• keep: This is a named vector of items you want to keep in the final rxode2 dataset. For added rxode2 event records (if seen), last observation carried forward will be used.

• addlKeepsCov: This determines if the additional dosing items repeats the dose only (FALSE) or keeps the covariates at the record of the dose (TRUE)

• addlDropSs: When there are steady state doses with an addl

  specification the steady state flag is dropped with repeated doses (when TRUE) or retained (when FALSE)

• ssAtDoseTime: Boolean that when TRUE back calculates the steady concentration at the actual time of dose, otherwise when FALSE the doses are shifted

• iCov: A data frame of individual non-time varying covariates to combine with the events dataset. The iCov dataset has one covariate per ID and should match the event table

Returns

Object for solving in rxode2