rxode2-set function

Set the function body of an rxUi object while retaining other object information (like data)

rxode2(x, envir = environment(x)) <- value

## S3 replacement method for class '`function`'
rxode2(x, envir = environment(x)) <- value

## Default S3 replacement method:
rxode2(x, envir = environment(x)) <- value

rxode(x, envir = environment(x)) <- value

RxODE(x, envir = environment(x)) <- value

Arguments

• x: The rxUi object
• envir: environment where the assignment ocurs
• value: the value that will be assigned

Returns

The rxode2 ui/function

Examples

one.compartment <- function() {
  ini({
    tka <- log(1.57); label("Ka")
    tcl <- log(2.72); label("Cl")
    tv <- log(31.5); label("V")
    eta.ka ~ 0.6
    eta.cl ~ 0.3
    eta.v ~ 0.1
    add.sd <- 0.7
  })
  model({
    ka <- exp(tka + eta.ka)
    cl <- exp(tcl + eta.cl)
    v <- exp(tv + eta.v)
    d/dt(depot) = -ka * depot
    d/dt(center) = ka * depot - cl / v * center
    cp = center / v
    cp ~ add(add.sd)
  })
}

two.compartment <- function() {
  ini({
    lka <- 0.45 ; label("Absorption rate (Ka)")
    lcl <- 1 ; label("Clearance (CL)")
    lvc  <- 3 ; label("Central volume of distribution (V)")
    lvp  <- 5 ; label("Peripheral volume of distribution (Vp)")
    lq  <- 0.1 ; label("Intercompartmental clearance (Q)")
    propSd <- 0.5 ; label("Proportional residual error (fraction)")
  })
  model({
    ka <- exp(lka)
    cl <- exp(lcl)
    vc <- exp(lvc)
    vp <- exp(lvp)
    q  <- exp(lq)
    kel <- cl/vc
    k12 <- q/vc
    k21 <- q/vp
    d/dt(depot) <- -ka*depot
    d/dt(central) <-  ka*depot - kel*central - k12*central + k21*peripheral1
    d/dt(peripheral1) <- k12*central - k21*peripheral1
    cp <- central / vc
    cp ~ prop(propSd)
  })
}

ui <- rxode2(one.compartment)

rxode2(ui) <- two.compartment