simFastBOIN1.3.2 package

Fast Bayesian Optimal Interval Design for Phase I Dose-Finding Trials

get_boin_boundary

Calculate BOIN Escalation and De-escalation Boundaries

get_boin_decision

Generate Dose Decision Table for BOIN Design

get_boin_stopping_boundaries

Generate Trial Stopping Rule Table

get_pts_and_tox

Generate Patient and Toxicity Data for BOIN Simulations

isotonic_regression

Isotonic Regression for Toxicity Rate Estimation

print.boin_multi_summary

Print Method for BOIN Multi-Scenario Summary

print.boin_summary

Print Method for BOIN Summary Objects

select_mtd

MTD Selection for Multiple Trials

sim_boin_multi

Run BOIN Simulation for Multiple Scenarios

sim_boin

Run BOIN Simulation with Operating Characteristics

Download source packageRead PDF manual

Conducting Bayesian Optimal Interval (BOIN) design for phase I dose-finding trials. 'simFastBOIN' provides functions for pre-computing decision tables, conducting trial simulations, and evaluating operating characteristics. The package uses vectorized operations and the Iso::pava() function for isotonic regression to achieve efficient performance while maintaining full compatibility with BOIN methodology. Version 1.3.2 adds p_saf and p_tox parameters for customizable safety and toxicity thresholds. Version 1.3.1 fixes Date field. Version 1.2.1 adds comprehensive 'roxygen2' documentation and enhanced print formatting with flexible table output options. Version 1.2.0 integrated C-based PAVA for isotonic regression. Version 1.1.0 introduced conservative MTD selection (boundMTD) and flexible early stopping rules (n_earlystop_rule). Methods are described in Liu and Yuan (2015) <doi:10.1111/rssc.12089>.

  • Maintainer: Gosuke Homma
  • License: MIT + file LICENSE
  • Last published: 2025-12-17

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