Design and Simulation of Seamless Phase II-III Clinical Trials
Given the estimates of the and , compute .
Compute the estimate of the variance of the generalized likelihood rat...
Analyses the results of running a design. If a trial history, such as ...
Given interim data, compute the response end-point summary
Given a design object, interim data and the current calendar time, con...
Explore a specified design by simulation
A function to generate some clinical trial data according the joint mo...
Generate interim data for a clinical trial from a data set.
Generate a seamless Phase II-III design object given some the true par...
A utility function to compute the hessian of the generalized (conditio...
Compute the response log-likelihood
Computes the constrained response log-likelihood (on the alternative)
Computes the survival log-likelihood
Computes the constrained survival log-likelihood
Compute the modified Haybittle-Peto boundary
Compute the modified Haybittle-Peto boundary for the final look
Perform an interim look in a seamless Phase II-III clinical trial
Reset the design object so that counts and results are zeroed out
A convenience function to reduce dimension by solving for one variable...
sp23design: A package for the design, exploration and execution of sea...
Provides methods for generating, exploring and executing seamless Phase II-III designs of Lai, Lavori and Shih using generalized likelihood ratio statistics. Includes pdf and source files that describe the entire R implementation with the relevant mathematical details.