Positron Emission Tomography Time-Activity Curve Analysis
Creates a tac object from a data.frame
Load (+/- merge) ROIs for batch of participants
Calculate one or more models for a batch of participants
Obtain values from voistat files (using load_voistat() for a batch.
Convert radioactivity units
Cutoff value calculation using method described in Aizenstein et al. 2...
Distribution volume ratio (DVR) for one or more ROIs
Non-invasive reference Logan method for all ROIs in tac data
Non-invasive reference Logan method
Loads TAC from file for use by other functions (default is PMOD .tac f...
Reads PMOD .voistat files and optionally merges volume-weighted ROIs
Loads ROI volumes from file for use by other functions
Non-invasive reference Logan plot
Plots time activity curves from 1 or 2 participants or groups.
Dichotomize participants based on ROI cutoff values
Return a list of merged ROIs made up of the atomic ROIs in the AAL atl...
Return a list of larger ROIs made up of the ROIs in the Hammer's atlas...
Return a list of merged ROIs made up of atomic ROIs in the Hammer's at...
Return a list of merged ROIs made up of the atomic ROIs in the Hammer'...
Save a tac object as a .tac file
Subset PMOD tacs with or without PVC
Calculate average SUV over time window, or maximum SUV
Calculate weighted SUVRs for specified regions of interest
Calculate SUVRs for regions of interest with AUC from mid-frame times
Calculate weighted time-activity curves for specified regions of inter...
Calculate SUV from TAC
tacmagic: PET Analysis in R
To facilitate the analysis of positron emission tomography (PET) time activity curve (TAC) data, and to encourage open science and replicability, this package supports data loading and analysis of multiple TAC file formats. Functions are available to analyze loaded TAC data for individual participants or in batches. Major functionality includes weighted TAC merging by region of interest (ROI), calculating models including standardized uptake value ratio (SUVR) and distribution volume ratio (DVR, Logan et al. 1996 <doi:10.1097/00004647-199609000-00008>), basic plotting functions and calculation of cut-off values (Aizenstein et al. 2008 <doi:10.1001/archneur.65.11.1509>). Please see the walkthrough vignette for a detailed overview of 'tacmagic' functions.