Sample Size and Power Calculation for Two Co-Primary Endpoints
Calculate Correlation Bounds Between Two Binary Outcomes
Calculate Correlation Bounds Between Count and Continuous Outcomes
Probability Mass Function of Bivariate Binomial Distribution
Create Design Comparison Table for Two Co-Primary Endpoints
Plot Method for twoCoprimary Objects
Power Calculation for Two Co-Primary Binary Endpoints (Approximate)
Exact Power Calculation for Two Co-Primary Binary Endpoints
Power Calculation for Two Co-Primary Continuous Endpoints
Power Calculation for Two Co-Primary Mixed Endpoints
Power Calculation for Two Co-Primary Endpoints (Count and Continuous)
Print Method for twoCoprimary_table Objects
Print Method for twoCoprimary Objects
Rejection Region for Two-Arm Trials with a Single Binary Endpoint
Sample Size Calculation for a Single Binary Endpoint
Sample Size Calculation for a Single Continuous Endpoint
Sample Size Calculation for a Single Count Endpoint (Negative Binomial...
Sample Size Calculation for Two Co-Primary Binary Endpoints (Asymptoti...
Exact Sample Size Calculation for Two Co-Primary Binary Endpoints
Sample Size Calculation for Two Co-Primary Continuous Endpoints (Appro...
Sample Size Calculation for Two Co-Primary Endpoints: One Continuous a...
Sample Size Calculation for Two Co-Primary Endpoints: One Count and On...
Unified Interface for Two Co-Primary Binary Endpoints (Approximate Met...
Unified Interface for Two Co-Primary Binary Endpoints (Exact Methods)
Unified Interface for Two Co-Primary Continuous Endpoints
Unified Interface for Mixed Continuous and Binary Co-Primary Endpoints
Unified Interface for Mixed Count and Continuous Co-Primary Endpoints
Comprehensive functions to calculate sample size and power for clinical trials with two co-primary endpoints. The package supports five endpoint combinations: two continuous endpoints (Sozu et al. 2011 <doi:10.1080/10543406.2011.551329>), two binary endpoints using asymptotic methods (Sozu et al. 2010 <doi:10.1002/sim.3972>) and exact methods (Homma and Yoshida 2025 <doi:10.1177/09622802251368697>), mixed continuous and binary endpoints (Sozu et al. 2012 <doi:10.1002/bimj.201100221>), and mixed count and continuous endpoints (Homma and Yoshida 2024 <doi:10.1002/pst.2337>). All methods appropriately account for correlation between endpoints and provide both sample size and power calculation capabilities.
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