Removal of Unwanted Technical Variation from UK Biobank NMR Metabolomics Biomarker Data
Aggregate QC Flags when computing the extended set of biomarker ratios
Compute extended set of biomarker ratios
Extract NMR biomarker QC flags from a data.frame of UK Biobank fields
Extract NMR metabolomic biomarkers from a data.frame of UK Biobank fie...
Extract NMR sample QC flags from a data.frame of UK Biobank fields
Aggregate QC Flags when recomputing all composite and derived biomarke...
Recompute composite biomarkers and ratios from the 107 non-derived bio...
Remove technical variation from NMR biomarker data in UK Biobank.
Tools for processing the UK Biobank NMR metabolomics biomarker data
A suite of utilities for working with the UK Biobank <https://www.ukbiobank.ac.uk/> Nuclear Magnetic Resonance spectroscopy (NMR) metabolomics data <https://biobank.ndph.ox.ac.uk/showcase/label.cgi?id=220>. Includes functions for extracting biomarkers from decoded UK Biobank field data, removing unwanted technical variation from biomarker concentrations, computing an extended set of lipid, fatty acid, and cholesterol fractions, and for re-deriving composite biomarkers and ratios after adjusting data for unwanted biological variation. For further details on methods see Ritchie SC et al. Sci Data (2023) <doi:10.1038/s41597-023-01949-y>.