Statistical Tools for Immune Correlates Analysis of Vaccine Clinical Trial Data
Create table of estimates
Run diagnostics
Estimate controlled effect curves
Estimate mediation effects
Estimate overall risk and vaccine efficacy
Load and format data object
Set parameters controlling Cox model estimation of controlled effect c...
Set parameters controlling nonparametric estimation of controlled effe...
Set parameters controlling nonparametric estimation of mediation effec...
Plotting controlled effect curves
Calculate summary statistics
Trim data for plotting/reporting
vaccine: Statistical Tools for Immune Correlates Analysis of Vaccine C...
Various semiparametric and nonparametric statistical tools for immune correlates analysis of vaccine clinical trial data. This includes calculation of summary statistics and estimation of risk, vaccine efficacy, controlled effects (controlled risk and controlled vaccine efficacy), and mediation effects (natural direct effect, natural indirect effect, proportion mediated). See Gilbert P, Fong Y, Kenny A, and Carone, M (2022) <doi:10.1093/biostatistics/kxac024> and Fay MP and Follmann DA (2023) <doi:10.48550/arXiv.2208.06465>.