Assurance Methods for Clinical Trials with a Delayed Treatment Effect
Add recruitment time to a survival dataset
Launch the 'shiny' adaptive assurance app
Launch the 'shiny' Assurance app
Calculate Bayesian Predictive Probability given interim data and poste...
Calculates operating characteristics for a Group Sequential Trial with...
Calculate Assurance for a Trial with a Delayed Treatment Effect
Function to calculate the 'optimal' BPP threshold value
Function to calculate the 'optimal' information fraction to calculate ...
Censor a survival dataset
Pipe operator
Simulates survival times for a delayed treatment effect (DTE) scenario...
Calculate statistical significance on a survival dataset
Update prior distributions using interim survival data
Package imports
Provides functions for planning clinical trials subject to a delayed treatment effect using assurance-based methods. Includes two 'shiny' applications for interactive exploration, simulation, and visualisation of trial designs and outcomes. The methodology is described in: Salsbury JA, Oakley JE, Julious SA, Hampson LV (2024) "Assurance methods for designing a clinical trial with a delayed treatment effect" <doi:10.1002/sim.10136>, Salsbury JA, Oakley JE, Julious SA, Hampson LV (2024) "Adaptive clinical trial design with delayed treatment effects using elicited prior distributions" <doi:10.48550/arXiv.2509.07602>.