Objective Comparison of Phase I Dose-Finding Designs
Generate Decision Tables with S3 Support
Design Constructor Functions
FIND: Compare Objective Decision Tables for Phase I Dose-Finding Desig...
Generate the decision table(s) for a single or multiple designs
Generate the plot(s) displaying operating characteristics for a single...
Dosing decision for the 3+3 design
Dosing decision for the BOIN design
Dosing decision for the G3 design
Dosing decision for the i3+3 design
Dosing decision for the mTPI2 design
Generate Decision Tables for Phase I Dose-Finding Designs
Load several commonly used scenarios
Generate Operating Characteristics Plots with S3 Support
Simulations for the 3+3 design.
Simulations for the BOIN design.
Simulations for the G3 design.
Simulations for the i3+3 design.
Simulations for the mTPI2 design.
Run Simulations for Phase I Dose-Finding Designs
Select the maximum tolerated dose (MTD) using isotonic regression
Summarize after conducting simulations
Generate decision tables and simulate operating characteristics for phase I dose-finding designs to enable objective comparison across methods. Supported designs include the traditional 3+3, Bayesian Optimal Interval (BOIN) (Liu and Yuan (2015) <doi:10.1158/1078-0432.CCR-14-1526>), modified Toxicity Probability Interval-2 (mTPI-2) (Guo et al. (2017) <doi:10.1002/sim.7185>), interval 3+3 (i3+3) (Liu et al. (2020) <doi:10.1177/0962280220939123>), and Generalized 3+3 (G3). Provides visualization tools for comparing decision rules and operating characteristics across multiple designs simultaneously.