The Integrated and Robust Deconvolution
Evaluation for estimated cell type proportions
Pseudo bulk data generation function
Extract the estimated proportions from InteRD
The InteRD1 estimate from reference ensemble
The InteRD2 estimate
Calculate the population-level cell type proportions from a single-cel...
A reference-free deconvolution estimate
We developed the Integrated and Robust Deconvolution algorithm to infer cell-type proportions from target bulk RNA-seq data. This package is able to effectively integrate deconvolution results from multiple scRNA-seq datasets and calibrates estimates from reference-based deconvolution by taking into account extra biological information as priors. Moreover, the proposed algorithm is robust to inaccurate external information imposed in the deconvolution system.