quadratic function

Quadratic model

The model function for the quadratic model is defined as [REMOVE_ME]$f(d,\theta)=E_0+\beta_1d+\beta_2d^2f(d,theta)=E0+beta1 d+beta2 d^2. [REMOVE_ME_2]$

Description

The model function for the quadratic model is defined as

quadratic(dose, e0, b1, b2)

Arguments

• dose: Dose variable
• e0: Placebo effect
• b1: beta1 parameter
• b2: beta2 parameter (controls, whether model is convex or concave)

Details

This model is intended to capture a possible non-monotonic dose-response relationship.

Returns

Response value

References

Pinheiro, J. C., Bretz, F. and Branson, M. (2006). Analysis of dose-response studies - modeling approaches, in N. Ting (ed.). Dose Finding in Drug Development, Springer, New York, pp. 146--171

See Also

logistic, sigEmax, linlog, linear, exponential, emax, betaMod