cubeECHACR function

Inheritance Cube: ECHACR

This function creates an ECHACR construct, it has 5 alleles at the first locus and 4 alleles at the second.

• W: Wild-type
• H: Homing allele
• E: Eraser allele
• R: No-cost resistance allele
• B: Detrimental resistance allele
• cHW: Rate of homing from H, W -> H transition
• cEH: Rate of homing from E, H -> E transition
• cEW: Rate of homing from E, W -> E transition

cubeECHACR(
  cHW = 1,
  cEW = 1,
  cEH = 1,
  chHW = 0,
  crHW = 0,
  ceEW = 0,
  crEW = 0,
  ceEH = 0,
  crEH = 0,
  d1 = 0,
  d2 = 0,
  d3 = 0,
  eta = NULL,
  phi = NULL,
  omega = NULL,
  xiF = NULL,
  xiM = NULL,
  s = NULL
)

Arguments

• cHW: Cutting efficiency of drive allele at locus 1
• cEW: Cutting efficiency of ECHACR element into W
• cEH: Cutting efficiency of ECHACR element into H
• chHW: Homing efficiency of drive allele at locus 1
• crHW: Resistance allele efficiency of drive allele at locus 1
• ceEW: Homing efficiency of ECHACR element into W
• crEW: Resistance allele efficiency of ECHACR element into W
• ceEH: Homing efficiency of ECHACR element into H
• crEH: Resistance allele efficiency of ECHACR element into H
• d1: Background mutation rate from W into R allele
• d2: Background mutation rate from H into R allele
• d3: Background mutation rate from E into R allele
• eta: Genotype-specific mating fitness
• phi: Genotype-specific sex ratio at emergence
• omega: Genotype-specific multiplicative modifier of adult mortality
• xiF: Genotype-specific female pupatory success
• xiM: Genotype-specific male pupatory success
• s: Genotype-specific fractional reduction(increase) in fertility

Returns

Named list containing the inheritance cube, transition matrix, genotypes, wild-type allele, and all genotype-specific parameters.

Details

This inheritance pattern corresponds to the Active Genetic Neutralizing Elements for Halting or Deleting Gene Drives publication.