MVEgger-class function

MVEgger Class

An object containing the estimates produced using the multivariable MR-Egger method as well as various statistics. class

Slots

• Model: Model always takes the value random, as only random-effects analyses are permitted.
• Orientate: The number of the risk factor that genetic associations are orientated to. The default value is 1, meaning that genetic associations with the first risk factor are set to be positive.
• Exposure: The names of the exposure variables.
• Outcome: The name of the outcome variable.
• Correlation: The matrix of correlations between genetic variants.
• Estimate: The causal estimates from the inverse-variance weighted method.
• StdError.Est: The standard errors associated with Estimate.
• CILower.Est: The lower bounds of the confidence interval for Estimate based on StdError.
• CIUpper.Est: The upper bounds of the confidence interval for Estimate based on StdError.
• Pvalue.Est: P-value associated with the causal estimate.
• Intercept: The intercept estimate from the MR-Egger method. Under the InSIDE assumption, the intercept represents the average pleiotropic effect (average direct effect on the outcome) of a genetic variant. If the intercept differs from zero, this is evidence that the genetic variants are not all valid instruments; specifically, there is directional pleiotropy.
• StdError.Int: The standard error associated with Intercept.
• CILower.Int: The lower bound of the confidence interval for Intercept based on StdError.Int.
• CIUpper.Int: The upper bound of the confidence interval for Estimate based on StdError.Int.
• Pvalue.Int: P-value associated with the intercept.
• Alpha: The significance level used in constructing the confidence interval (default is 0.05).
• SNPs: The number of SNPs that were used in the calculation.
• RSE: The estimated residual standard error from the regression model.
• Heter.Stat: Heterogeneity statistic (Cochran's Q statistic) and associated p-value: the null hypothesis is that all genetic variants estimate the same causal parameter; rejection of the null is an indication that one or more variants may be pleiotropic.