MVcML_SdTheta function

Standard error estimate for MVMR-cML-BIC

This is based on the profile likelihood of the set of valid IVs, which is not robust to uncertainty in model selection.

MVcML_SdTheta(b_exp, b_out, Sig_inv_l, theta, zero_ind, r_vec = NULL)

Arguments

• b_exp: A matrix of SNP effects on the exposure variable.
• b_out: A vector of SNP effects on the outcome variable.
• Sig_inv_l: A list of inverse of covariance matrix.
• theta: A vector of final estimates of causal effect of each exposure by MVMR-cML-BIC obtained from MVmr_cML_DP.
• zero_ind: A vector of the index of valid IVs.
• r_vec: A vector of estimated horizontal pleiotropic effects.

Returns

A vector