D1 function

Computing each element of the function c_weight_1

This function computes each element of the vector function c_weight_1 which is the first derivative of the c-optimality criterion with respect to the model parameters.

D1(T, x, xl, inv, p, order)

Arguments

• T: A numeric vector. Model parameter values
• x: A numeric. ith dose level for a given design
• xl: A numeric. last dose level for a given design
• inv: A numeric matrix. Inverse of the information matrix
• p: A numeric. Define EDp
• order: numeric. The number of model paraemters