c_weight_1 function

The first derivative of the c-optimality criterion w.r.t the model parameters

The first derivative of the c-optimality criterion with respect to the model parameters. This is a sub-function of c_weight to run one iteration of Newton-Raphson method.

c_weight_1(W, T, X, inv, p, order)

Arguments

• W: A numeric vector. The first K-1 weights for a given design
• T: A numeric vector. Model parameter values
• X: A numeric vector. K dose levels for a given design
• inv: A numeric matrix. Inverse of the information matrix.
• p: A numeric. Define EDp
• order: numeric. The number of model paraemters