OneCompIVbolus function

ADVAN-style equations

Adapted from Abuhelwa et al. JPET 2015

OneCompIVbolus(d)

Arguments

• d: data, a NONMEM style data frame for 1 subject with columns for TIME, AMT, MDV, DV, CL, V

Returns

Returns a dataframe with populated columns for A1, and DV

Details

Functions for calculating drug amount in each compartments of the common pharmacokinetic models (1,2,3 compartment IV bolus, IV infusion, and first-order absorption models)

Definitions:

• A*last: is the initial amount at the beginning of each time interval (t, t=t2-t1) of a corresponding compartment (i.e. drug amount at the end of the last time interval)
• E* : the sum of Exit (elimination) rate constant of the corresponding compartment. IV bolus- 1 compartment

References

Abuhelwa, A. Y., Foster, D. J. R., Upton, R. N. (2015) ADVAN-style analytical solutions for common pharmacokinetic models. J Pharmacol Toxicol Methods 73:42-8. DOI: 10.1016/j.vascn.2015.03.004