PKPDsim1.4.0 package

Join two dosing regimens

Size of the lower triangle of the matrix

Merge two regimens together.

Load model definition from API, and compile to R library

Model library

More powerful multivariate normal sampling function

Fill in NAs with the previous non-missing value

Probabilistically model adherence

covariate model function

Combines covariates and parameters into a single list, useful for repa...

ADVAN-style functions to calculate linear PK systems

Wrapper for using analytical equations with PKPD regimens

defines C code for TDM before dose conditions

Auto-detect the syntax for the ODE code

covariate function builder

Put vector values in quotes

Calculate the increase in a specific quantile for a distribution on y ...

Add residual variability to the dependent variable

Binomial adherence

Markov adherence model

Create ADVAN-style dataset

Internal function to parse the raw output from ADVAN-style functions

Add column RATEALL to ADVAN-style dataset to handle infusions

Apply infusion duration scale to a regimen

Apply lagtime to a regimen

See models from the literature available for installation

Transforms bioavailability specs into appropriate R code

Convenience function to calculate the AUC based on PK model parameters...

Calculate derivative

Returns the state of a linear PK system at steady state (trough) using...

Get fixed parameters from model definition.

Calculate model-specific variables using a dummy call to sim_ode()

Checks that IOV was specified appropriately

Check that mixture model is specified in right format and within const...

Checks obs input for valid combinations of cmt, var, scale

Compile ODE model to c++ function

Use only last observed covariate values

Convert covariate table specified as data.frame

Create an event table

Create obs data

Create lower-diagonal omega matrix from CV for parameter estimates

Functions for getting information about a model

Get the number of states in the ODE from the code code C++ code for mo...

Get model parameters from code

Extract sensible default observation times from a specified regimen

Get expected variance/sd/ci of dependent variable based on PKPDsim mod...

ifelse function but then based on whether value is NULL or not

Install default literature model

Check if package number is different from currently installed, and pro...

Is matrix positive definite

New covariate

Create new ODE model

Dose regimen for sim_ode

Function to parse parameters for a model into a structure used by nlmi...

Create a regimen from NONMEM data

Current time in UTC

ADVAN-style equations

IV infusion- 1 compartment

first-order absorption 1 compartment

Parse observation types to simulation code

Convert a model generated with PKPDsim to an object for nlmixr

PKPDsim package

Remove n doses (from tail) of PKPDsim regimen

Return a list in R syntax

Print function for PKPDsim covariate object

Print function for PKPDsim simulation function

Print function for PKPDsim regimen

Read model definition from JSON

Convert PKPDsim regimen to NONMEM table (doses only)

Reparametrize model parameters using a reparametrization defined withi...

Find string and replace in file

Remove n doses (from start) of PKPDsim regimen

R starts counting vector indices at 1, c++ starts at 0, so reduce all ...

Transform a vector into a string that evaluates to the same vector

Only core function of the simulation function, always just returns obs...

Simulate ODE and create a Shiny app

Deprecated function, renamed to sim()

Simulate ODE or analytical equation

Convert a table to a list

Test a model

Test if model still in memory

IV bolus- 3 compartment

IV infusion- 3 compartment

3-compartment IV infusion with first-order metabolite formation

first-order absorption- 3 compartment

first-order absorption- 3 compartment-Metabolite

Translate a model from/to various PKPD simulators

Convert triangle omega matrix to full omega matrix

IV bolus- 2 compartment

IV infusion- 2 compartment

First-order absorption- 2 compartment