calculate_parameters function

Calculate model-specific variables using a dummy call to sim_ode()

This is a convenience function for PKPDsim users, it is not used inside the sim_ode()`` function in any way. This function is useful for convertingfrom an estimated parameter to actual parameter, e.g. when clearance isspecified asCLi = CL * (WT/70) * (1/CR)it can be used to calculateCLi` without having to write that function a second time in R.

calculate_parameters(
  ode = NULL,
  parameters = NULL,
  covariates = NULL,
  include_parameters = TRUE,
  include_variables = TRUE,
  regimen = NULL,
  t_obs = NULL,
  ...
)

Arguments

• ode: PKPDsim model object
• parameters: parameter list
• covariates: covariate list. Make sure to include covariates at the right time point, since only last observed covariate values are used.
• include_parameters: boolean, include parameters?
• include_variables: boolean, include variables?
• regimen: optional, provide a regimen object for the computation of the effective parameters. This is only relevant for models for which parameters depend on the dose or administration type, which is rare.
• t_obs: optional, provide timepoint(s) at which to computate effective parameters. This is only relevant for models with time-varying fixed-effects. If unspecified, will evaluate parameters at t=0.
• ...: arguments to pass on to simulation function

Returns

List of model-specific variables