calc_auc_analytic function

Convenience function to calculate the AUC based on PK model parameters at any given moment, for linear iv models.

calc_auc_analytic(
  f = c("1cmt_iv_infusion", "2cmt_iv_infusion", "3cmt_iv_infusion", "1cmt_iv_bolus",
    "2cmt_iv_bolus", "3cmt_iv_bolus"),
  parameters,
  regimen = NULL,
  dose = NULL,
  interval = NULL,
  t_inf = NULL,
  t_obs = c(0, 24, 48, 72),
  ...
)

Arguments

• f: analytic model to use, show available models using advan()
• parameters: list of parameter estimates. Requires CL/V for 1-compartment models, CL/V/Q/V2 for 2-compartment models, and CL/V/Q/V2/Q2/V3 for 3-compartment models.
• regimen: PKPDsim regimen created using new_regimen. Not required, regimen can also be specified using dose, interval, and t_inf.
• dose: dosing amount for regimen (single value). Only used if no regimen supplied.
• interval: dosing interval for regimen (single value). Only used if no . regimen supplied.
• t_inf: infusion length for regimen (single value). Only used if no regimen supplied.
• t_obs: vector of observation times for AUC
• ...: optional arguments passed to advanc_create_data()

Returns

a data.frame with t and auc

Examples

dat <- calc_auc_analytic(
  f = "2cmt_iv_infusion",
  regimen = new_regimen(
    amt = 1000, n = 10, type = "infusion",
    t_inf = 1, interval = 24
  ),
  parameters = list(CL = 5, V = 50, Q = 8, V2 = 150)
)