Simulates SPSO and Efftox Phase 12 Trials with Correlated Outcomes
Simulates desirability based Efftox trials
Determines the optimal dose to assign the next patient cohort.
Generate binary bivariate data.
Returns the desireability value of a dose.
Assigns next patient cohort based on the Efftox model with a Desirabil...
Assigns next patient cohort based on the Efftox model with a Utility b...
Determines the optimal dose to assign the next patient cohort.
Returns prior dose-specific means and prior ESS for the SPSO model.
Assigns next patient cohort based on the SPSOP model with a Utility ba...
Assigns next patient cohort based on the SPSOP model with a Utility ba...
Obtains optimal dose level.
Simulates utility based Efftox trials
Simulates trial replications from the Efftox model with desirability o...
Simulates trial replications from the Efftox model with utility optima...
Simulates trial replications from the SPSO model with desirability opt...
Simulates trial replications from the SPSO model with desirability opt...
Samples from the posterior of the utility based phase12 model.
Simulating and conducting four phase 12 clinical trials with correlated binary bivariate outcomes described. Uses the 'Efftox' (efficacy and toxicity tradeoff, <https://biostatistics.mdanderson.org/SoftwareDownload/SingleSoftware/Index/2>) and SPSO (Semi-Parametric Stochastic Ordering) models with Utility and Desirability based objective functions for dose finding.