Sample Size Tables for the Classical 2x2 Crossover Design
These data.frames give sample size tables calculated with sampleN.TOST() for the 2 2 design.
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The data.frames can be accessed by their names.
| data.frame | Description |
| ct5.1 | Multiplicative model, theta1=0.8, theta2=1.25 (1/theta1), exact |
| ct5.2 | Multiplicative model, theta1=0.75, theta2=1.3333 (1/theta1), exact |
| ct5.3 | Multiplicative model, theta1=0.9, theta2=1.1111 (1/theta1), exact |
| ct5.4.1 | Additive model, theta1=--0.2, theta2=+0.2 (BE limits 0.80 -- 1.20), exact |
| data.frame | Origin | Details |
| ct5.1 | Hauschke et al. | Table 5.1 (p 113--114) |
| ct5.2 | Hauschke et al. | Table 5.2 (p 115--116) |
| ct5.3 | Hauschke et al. | Table 5.3 (p 118) |
| ct5.4.1 | Chow & Liu | Table 5.4.1 (p 158) |
Hauschke D, Steinijans VW, Pigeot I. Bioequivalence Studies in Drug Development. Chichester: John Wiley; 2007.
Chow SC, Liu JP. Design and Analysis of Bioavailability and Bioequivalence Studies. Boca Raton: CRC Press; 3 edition 2009.
Scripts for creation of these data.frames can be found in the /tests
sub-directory of the package.
Comparing the results of these scripts to the corresponding data.frames can be used for validation purposes.
PowerTOST
ct5.1 ct5.2 ct5.3 ct5.4.1