KO_enrich function

Perform enrichment analysis

This function performs KO enrichment analysis using the clusterProfiler package.

KO_enrich(
  ko_stat,
  padj_threshold = 0.05,
  logFC_threshold = NULL,
  add_mini = NULL,
  p.adjust.method = "BH",
  type = c("pathway", "module")[1],
  feature = "ko",
  modulelist = NULL,
  verbose = TRUE
)

as.enrich_res(gsea_res)

Arguments

• ko_stat: ko_stat dataframe from ko.test.
• padj_threshold: p.adjust threshold to determine whether a feature significant or not. p.adjust < padj_threshold, default: 0.05
• logFC_threshold: logFC threshold to determine whether a feature significant or not. abs(logFC)>logFC_threshold, default: NULL
• add_mini: add_mini when calculate the logFC. e.g (10+0.1)/(0+0.1), default 0.05*min(avg_abundance)
• p.adjust.method: The method used for p-value adjustment (default: "BH").
• type: "pathway" or "module" for default KOlist_file.
• feature: one of "ko", "gene", "compound"
• modulelist: NULL or customized modulelist dataframe, must contain "id","K_num","KOs","Description" columns. Take the KOlist as example, use custom_modulelist.
• verbose: logical
• gsea_res: gsea_res from KO_gsea

Returns

A data frame containing the enrichment results.

enrich_res object

See Also

Other common_enrich: KO_fisher(), KO_gsa(), KO_gsea(), KO_gsva(), KO_padog(), KO_safe(), KO_sea(), plot_enrich_res()