aNCA0.1.0 package

Add bioavailability results to PKNCA results

Add impute method to the impute column

Helper function to handle optional layers

Add a slide with a plot only

Add a slide with both a plot and a table

Add a slide with a table only

Add a title slide to the rpptx document

Helper to create a Quarto code chunk for a plot

Add a slide to the Quarto document with a single plot

Add a slide to the Quarto document with a plot and two tables (side by...

Helper to create a Quarto code chunk for a table

Apply Filters to a Dataset

Apply Labels to a dataset

Apply UI-Based Column Mapping to a Dataset

Calculate bioavailability with pivoted output

Calculate Ratios from PKNCA Results

Calculate Summary Statistics

Check overlap between existing and new slope rulesets

Convert Numeric Value and Unit to ISO 8601 Duration

Convert Volume Units to Match Concentration Denominator Units

Render dose escalation results to HTML via Quarto

Create METABFL Column Based on Selected Metabolites

Create a new PowerPoint document from a template and add a title slide

Create a PowerPoint presentation with dose escalation results, includi...

Create a new Quarto presentation file with YAML header and setup chunk

Create all slides for dose escalation results in a Quarto document

Create C0 Impute Column

Detect study types

Create duplicates in concentration data with Pre-dose and Last Values ...

Apply Slope Rules to Update Data

Compresses a numeric vector into the simplest possible character strin...

Evaluates range notation. If provided notation is invalid, returns NA.

Generate an Empty Plotly Object

Ensure Unit Columns Exist in PKNCA Object

Export CDISC Data

Filter Breaks for X-Axis

Filter dataset based on slope selections and exclusions

Flexible Violin/Box Plot

Create PK Concentration Dataset

Create Dose Intervals Dataset

Create PK Dose Dataset

Formats a unit string if a unique unit exists

Wrapper around aNCA::pkcg01() function. Calls the function with LIN ...

Wrapper around aNCA::pkcg01() function. Calls the function with LOG ...

Wrapper around aNCA::pkcg02() function. Calls the function with LIN ...

Wrapper around aNCA::pkcg02() function. Calls the function with LOG ...

Generate a General Line Plot for ADNCA Dataset

Generate a Mean Concentration Plot for ADNCA Dataset

Generate HTML Tooltip Text

Transform Units

Get the Label of a Heading

Identify target rows based on groups, parameters, and impute method

Add specified imputation methods to the intervals in a PKNCAdata or da...

Remove specified imputation from the intervals in a PKNCAdata or data....

Create PK Concentration Listing

Generate a Lambda Slope Plot

Log conversions applied to dataset

Calculate Matrix Ratios This function calculates the ratios for a give...

Parses annotations in the context of data. Special characters and synt...

Reshape PKNCA Results

Create a PK Dose Quality Control (QC) Plot

Calculate the total urine volume

Generate PK Concentration-Time Profile Plots

Generate Combined PK Concentration-Time Profile Plot by Cohort

Build Units Table for PKNCA

Calculate bioavailability for intravascular vs extravascular aucs

Calculates results for PKNCA analysis.

Creates a PKNCA::PKNCAdata object.

Exclude NCA results based on user-defined rules over the half-life rel...

This function imputes the start concentration using the first concentr...

This function imputes the start concentration using the log slope meth...

Create a PKNCAdata Object for NCA or Slope Analysis

Prepare Data for PK Dose QC Plotting

Prepare Data for PK Lineplot

Reads PK datasets from various file formats.

Remove impute method from the impute column

Run the Shiny app

Find Minimal Grouping Columns for Strata Reconstruction

Simplify compound unit expressions

Translate Terms from One Nomenclature to Another

Validates data table with raw pk data.

Conditionally Verify and Override PK Parameters Based on Sample Type