print.threep3 function

Print information regarding the operating characteristics of a standard 3+3 design

Print method for a 3+3 design specified using a threep3.

## S3 method for class 'threep3'
print(x, tox.cutpoints = NULL, dose = NULL, ...)

Arguments

• x: An object of class "threep3" as returned by threep3

• tox.cutpoints: An optional argument passed to print.threep3

  specifying the cutpoints of toxicity for which the operating characteristics are to be categorised. Defaults to seq(from=0, to=1, by=0.2)

• dose: Optional vector of length k of actual doses for presentation purposes

• ...: Further arguments passed to or from other methods

Details

The following operating characteristics are printed for the standard 3+3 design:

• Sample size: Mean, minimum and maximum sample size of the design
• Experimentation proportion: Proportion of patients recruited to each dose, and to each true region of toxicity, on average
• Recommendation proportion: Proportion of 3+3 trials that would recommend each of the dose levels as the final maximum tolerated dose (see threep3 for definition of the MTD), and the associated regions of true toxicity for the recommended MTDs
• Average number of patients: The average number of patients dosed at each level
• Average number of DLTs: The average number of DLTs seen at each level

References

Sweeting M., Mander A., Sabin T. bcrm: Bayesian Continual Reassessment Method Designs for Phase I Dose-Finding Trials. Journal of Statistical Software (2013) 54: 1--26. http://www.jstatsoft.org/article/view/v054i13

See Also

threep3

Author(s)

Michael Sweeting mjs212@medschl.cam.ac.uk (University of Cambridge, UK)