Bayesian Continual Reassessment Method for Phase I Dose-Escalation Trials
Bayesian Continual Reassessment Method for Phase I Dose-Escalation Tri...
Bayesian Continual Reassessment Method for Phase I Dose-Escalation Tri...
Obtain samples from the maximum tolerated dose (MTD) distribution.
Samples from the specified prior distribution.
Plot the estimated dose-toxicity curve
Plot the operating characteristics from the simulated trials
Plot the operating characteristics from a standard 3+3 trial
Returns samples from the posterior distributions of each model paramet...
Returns posterior mean parameter value and summaries of distributions ...
Returns posterior mean parameter value and summaries of distributions ...
Returns samples from the posterior distributions of each model paramet...
Returns samples from the posterior distributions of each model paramet...
Print information regarding a trial conducted using the Bayesian conti...
Print information regarding the operating characteristics of a standar...
Calculate all possible trial pathways for the standard 3+3 design, tog...
Implements a wide variety of one- and two-parameter Bayesian CRM designs. The program can run interactively, allowing the user to enter outcomes after each cohort has been recruited, or via simulation to assess operating characteristics. See Sweeting et al. (2013): <doi:10.18637/jss.v054.i13>.