# Summarize the dual-endpoint design simulations, relative to given true dose-toxicity and dose-biomarker curves ```r ## S4 method for signature 'DualSimulations' summary(object, trueTox, trueBiomarker, target = c(0.2, 0.35), ...) ``` ## Arguments - `object`: the `DualSimulations` object we want to summarize - `trueTox`: a function which takes as input a dose (vector) and returns the true probability (vector) for toxicity. - `trueBiomarker`: a function which takes as input a dose (vector) and returns the true biomarker level (vector). - `target`: the target toxicity interval (default: 20-35%) used for the computations - ``...``: Additional arguments can be supplied here for `trueTox` and `trueBiomarker` ## Returns an object of class `DualSimulationsSummary` ## Examples ```r # Define the dose-grid emptydata <- DataDual(doseGrid = c(1, 3, 5, 10, 15, 20, 25, 40, 50, 80, 100)) # Initialize the CRM model model <- DualEndpointRW(mu = c(0, 1), Sigma = matrix(c(1, 0, 0, 1), nrow=2), sigma2betaW = 0.01, sigma2W = c(a=0.1, b=0.1), rho = c(a=1, b=1), smooth="RW1") # Choose the rule for selecting the next dose myNextBest <- NextBestDualEndpoint(target=c(0.9, 1), overdose=c(0.35, 1), maxOverdoseProb=0.25) # Choose the rule for stopping myStopping4 <- StoppingTargetBiomarker(target=c(0.9, 1), prob=0.5) # StoppingMinPatients will usually take a higher sample size, # just for illustration here myStopping <- myStopping4 | StoppingMinPatients(6) # Choose the rule for dose increments myIncrements <- IncrementsRelative(intervals=c(0, 20), increments=c(1, 0.33)) # Initialize the design design <- DualDesign(model = model, data = emptydata, nextBest = myNextBest, stopping = myStopping, increments = myIncrements, cohortSize = CohortSizeConst(3), startingDose = 3) # define scenarios for the TRUE toxicity and efficacy profiles betaMod <- function (dose, e0, eMax, delta1, delta2, scal) { maxDens <- (delta1^delta1) * (delta2^delta2)/((delta1 + delta2)^(delta1 + delta2)) dose <- dose/scal e0 + eMax/maxDens * (dose^delta1) * (1 - dose)^delta2 } trueBiomarker <- function(dose) { betaMod(dose, e0=0.2, eMax=0.6, delta1=5, delta2=5 * 0.5 / 0.5, scal=100) } trueTox <- function(dose) { pnorm((dose-60)/10) } # Draw the TRUE profiles par(mfrow=c(1, 2)) curve(trueTox(x), from=0, to=80) curve(trueBiomarker(x), from=0, to=80) # Run the simulation on the desired design # We only generate 1 trial outcome here for illustration, for the actual study # Also for illustration purpose, we will use 5 burn-ins to generate 20 samples # this should be increased of course! mySims <- simulate(design, trueTox=trueTox, trueBiomarker=trueBiomarker, sigma2W=0.01, rho=0, nsim=1, parallel=FALSE, seed=3, startingDose=6, mcmcOptions = McmcOptions(burnin=5, step=1, samples=20)) # Summarize the Results of the Simulations summary(mySims, trueTox = trueTox, trueBiomarker = trueBiomarker) ```

summary-DualSimulations-method function