Object-Oriented Implementation of Dose Escalation Designs
| Package name | Version | Title | Date | Size | License | |
|---|---|---|---|---|---|---|
| crmPack | 2.0.0 | Object-Oriented Implementation of Dose Escalation Designs | Sat Nov 29 2025 | 5607.95kB | GPL (>= 2) | |
| crmPack | 1.0.6 | Object-Oriented Implementation of CRM Designs | Wed Jun 26 2024 | 673.27kB | GPL (>= 2) | |
| crmPack | 1.0.5 | Object-Oriented Implementation of CRM Designs | Sun Feb 04 2024 | 707.83kB | GPL (>= 2) | |
| crmPack | 1.0.4 | Object-Oriented Implementation of CRM Designs | Tue Jan 23 2024 | 712.80kB | GPL (>= 2) | |
| crmPack | 1.0.3 | Object-Oriented Implementation of CRM Designs | Fri Sep 02 2022 | 1029.09kB | GPL (>= 2) | |
| crmPack | 1.0.2 | Object-Oriented Implementation of CRM Designs | Mon Apr 25 2022 | 1145.41kB | GPL (>= 2) | |
| crmPack | 1.0.0 | Object-Oriented Implementation of CRM Designs | Thu Jun 13 2019 | 1708.53kB | GPL (>= 2) | |
| crmPack | 0.2.9 | Object-Oriented Implementation of CRM Designs | Fri Dec 21 2018 | 1720.15kB | GPL (>= 2) | |
| crmPack | 0.2.7 | Object-Oriented Implementation of CRM Designs | Tue Mar 13 2018 | 1144.82kB | GPL (>= 2) | |
| crmPack | 0.2.6 | Object-Oriented Implementation of CRM Designs | Thu Feb 15 2018 | 1145.54kB | GPL (>= 2) | |
| crmPack | 0.2.1 | Object-Oriented Implementation of CRM Designs | Wed May 03 2017 | 1139.89kB | GPL (>= 2) | |
| crmPack | 0.2.0 | Object-Oriented Implementation of CRM Designs | Sat Jul 16 2016 | 1449.28kB | GPL (>= 2) | |
| crmPack | 0.1.9 | Object-Oriented Implementation of CRM Designs | Mon Feb 29 2016 | 1435.99kB | GPL (>= 2) | |
| crmPack | 0.1.8 | Object-Oriented Implementation of CRM Designs | Wed Feb 17 2016 | 1439.27kB | GPL (>= 2) | |
| crmPack | 0.1.7 | Object-Oriented Implementation of CRM Designs | Tue Jan 26 2016 | 1438.78kB | GPL (>= 2) | |
| crmPack | 0.1.6 | Object-Oriented Implementation of CRM Designs | Tue Dec 22 2015 | 1439.98kB | GPL (>= 2) | |
| crmPack | 0.1.5 | Object-Oriented Implementation of CRM Designs | Thu Nov 12 2015 | 1439.30kB | GPL (>= 2) |
Implements a wide range of dose escalation designs. The focus is on model-based designs, ranging from classical and modern continual reassessment methods (CRMs) based on dose-limiting toxicity endpoints to dual-endpoint designs taking into account a biomarker/efficacy outcome. Bayesian inference is performed via MCMC sampling in JAGS, and it is easy to setup a new design with custom JAGS code. However, it is also possible to implement 3+3 designs for comparison or models with non-Bayesian estimation. The whole package is written in a modular form in the S4 class system, making it very flexible for adaptation to new models, escalation or stopping rules. Further details are presented in Sabanes Bove et al. (2019) <doi:10.18637/jss.v089.i10>.
Useful links