accuracy_index function

Accuracy Index

Calculate the Accuracy Index.

accuracy_index(
  mtd_estimate,
  dose_set,
  true_prob,
  theta,
  loss = c("squared", "absolute", "classification", "overdose"),
  alpha = NULL
)

Arguments

• mtd_estimate: a numerical vector of the MTD estimates.
• dose_set: a numerical vector of allowable doses in the trial.
• true_prob: a numerical vector of the true probabilities associated with 'dose_set'.
• theta: a numerical value defining the proportion of expected patients to experience a medically unacceptable, dose-limiting toxicity (DLT) if administered the MTD.
• loss: a loss function between the true probabilities of toxicity 'true_prob' and the target DLT rate 'theta'.
• alpha: a numerical value indicating the weight of overdose for the overdose loss function.

Returns

Accuracy Index for given loss function of the MTD estimates.

References

Cheung, Y. K. (2011). Dose finding by the continual reassessment method. CRC Press.