dlt_curve_d1ph function

Plot the DLT curve based on the EWOC proportional hazards model

Plot the DLT curve based on the EWOC proportional hazards model

dlt_curve_d1ph( mtd, rho, theta, min_dose, max_dose, shape, tau, distribution = "exponential", dose_set = NULL )

Arguments

  • mtd: a numerical value indicating the true value of the parameter mtd.
  • rho: a numerical value indicating the true value of the parameter rho.
  • theta: a numerical value defining the proportion of expected patients to experience a medically unacceptable, dose-limiting toxicity (DLT) if administered the MTD.
  • min_dose: a numerical value defining the lower bound of the support of the MTD.
  • max_dose: a numerical value defining the upper bound of the support of the MTD.
  • shape: a numerical value indicating the true value of the parameter shape. It is only necessary if 'distribution' = "weibull".
  • tau: a numerical value defining the period of time for a possible toxicity be observed.
  • distribution: a character establishing the distribution for the time of events. It can be defined as 'exponential' or 'weibull'.
  • dose_set: a numerical vector of doses that probability of DLT will be calculated.
  • Maintainer: Marcio A. Diniz
  • License: GPL (>= 2)
  • Last published: 2020-06-07