mtd_rho_d1extended function

Convert mtd to rho_1 and vice-versa

Convert mtd to rho_1 and vice-versa

Converting mtd to rho_1 given rho_0 for EWOC design using extended parametrization and vice-versa.

mtd_rho_d1extended(mtd = NULL, rho_1 = NULL, rho_0, theta, min_dose, max_dose)

Arguments

  • mtd: a numerical value defining the mtd value to be converted into rho_1 value.
  • rho_1: a numerical value defining the probability of DLT at the max_dose.
  • rho_0: a numerical value defining the probability of DLT at the min_dose.
  • theta: a numerical value defining the proportion of expected patients to experience a medically unacceptable, dose-limiting toxicity (DLT) if administered the MTD.
  • min_dose: a numerical value defining the lower bound of the support of the MTD.
  • max_dose: a numerical value defining the upper bound of the support of the MTD.

Returns

mtd a numerical value for the maximum tolerable dose.

rho_1 a numerical value for the probability of DLT at the max_dose.

  • Maintainer: Marcio A. Diniz
  • License: GPL (>= 2)
  • Last published: 2020-06-07