pdlt_d1classical function

Generating a probability of DLT function based on the EWOC classical model

pdlt_d1classical(rho, mtd, theta, min_dose, max_dose)

Arguments

• rho: a numerical value indicating the true value of the parameter rho.
• mtd: a numerical value indicating the true value of the parameter mtd.
• theta: a numerical value defining the proportion of expected patients to experience a medically unacceptable, dose-limiting toxicity (DLT) if administered the MTD.
• min_dose: a numerical value defining the lower bound of the support of the MTD.
• max_dose: a numerical value defining the upper bound of the support of the MTD.

Returns

A function with dose as an input and a probability based on the logistic regression and parameters as an output.

Examples

pdlt <- pdlt_d1classical(rho = 0.05, mtd = 60, theta = 0.33,
                      min_dose = 20, max_dose = 100)

pdlt(20)