pdlt_d1ph function

Generating a probability of DLT function based on the EWOC Proportional Hazards model

pdlt_d1ph(rho, mtd, shape = NULL, theta, min_dose, max_dose, tau, distribution)

Arguments

• rho: a numerical value indicating the true value of the parameter rho.
• mtd: a numerical value indicating the true value of the parameter mtd.
• shape: a numerical value indicating the true value of the parameter shape. It is only necessary if 'distribution' = "weibull".
• theta: a numerical value defining the proportion of expected patients to experience a medically unacceptable, dose-limiting toxicity (DLT) if administered the MTD.
• min_dose: a numerical value defining the lower bound of the support of the MTD.
• max_dose: a numerical value defining the upper bound of the support of the MTD.
• tau: a numerical value defining the period of time for a possible toxicity be observed.
• distribution: a character establishing the distribution for the time of events. It can be defined as 'exponential' or 'weibull'.

Returns

A function with dose as an input and a probability based on the logistic regression and parameters as an output.

Examples

pdlt <- pdlt_d1ph(rho = 0.05, mtd = 40, theta = 0.33,
                 min_dose = 30, max_dose = 50,
                 tau = 10, distribution = "exponential")
pdlt(40)