response_d1ph function

Generating a response function based on the EWOC Proportional Hazards model

response_d1ph(
  rho,
  mtd,
  theta,
  min_dose,
  max_dose,
  tau,
  distribution,
  shape = NULL
)

Arguments

• rho: a numerical value indicating the true value of the parameter rho.
• mtd: a numerical value indicating the true value of the parameter mtd.
• theta: a numerical value defining the proportion of expected patients to experience a medically unacceptable, dose-limiting toxicity (DLT) if administered the MTD.
• min_dose: a numerical value defining the lower bound of the support of the MTD.
• max_dose: a numerical value defining the upper bound of the support of the MTD.
• tau: a numerical value defining the period of time for a possible toxicity be observed.
• distribution: a character establishing the distribution for the time of events.
• shape: a numerical value indicating the true value of the parameter shape. It is only necessary if 'distribution' = "weibull".

Returns

A function with dose as an input and a Binomial variable based on the parameters as an output.

Examples

response_sim <- response_d1ph(rho = 0.05, mtd = 40, theta = 0.33,
                             min_dose = 30, max_dose = 50,
                             tau = 10, distribution = "exponential")
response_sim(40)