stop_rule_d1classical function

Generating a stop rule function for EWOC classical model

stop_rule_d1classical(step)

Arguments

• step: an object from the class 'ewoc_d1classical'.

Returns

a logical character indicating if the trial should be stopped or not.

Details

The stop rule function is evaluated at each step of the trial. It can defined based on any information contained in the object 'step' that is the output from one of the functions 'ewoc_d1classical'.

Examples

## Not run:

DLT <- 0
dose <- 20
step_zero <- ewoc_d1classical(DLT ~ dose, type = 'discrete',
                           theta = 0.33, alpha = 0.25,
                           min_dose = 0, max_dose = 100,
                           dose_set = seq(0, 100, 20),
                           rho_prior = matrix(1, ncol = 2, nrow = 1),
                           mtd_prior = matrix(1, ncol = 2, nrow = 1),
                           rounding = "nearest")
stop_rule_d1classical(step_zero)
response_sim <- response_d1classical(rho = 0.05, mtd = 20, theta = 0.33,
                                  min_dose = 10, max_dose = 50)
sim <- ewoc_simulation(step_zero = step_zero,
                       n_sim = 2, sample_size = 30,
                       alpha_strategy = "conditional",
                       response_sim = response_sim,
                       stop_rule_sim = stop_rule_d1_classical,
                       ncores = 1)
## End(Not run)