stop_rule_d1extended function

Generating a stop rule function for EWOC extended model

stop_rule_d1extended(step)

Arguments

• step: an object from the class 'ewoc_d1extended'.

Returns

a logical character indicating if the trial should be stopped or not.

Details

The stop rule function is evaluated at each step of the trial. It can defined based on any information contained in the object 'step' that is the output from one of the functions ewoc_d1extended'.

Examples

## Not run:

DLT <- 0
dose <- 20
step_zero <- ewoc_d1extended(DLT ~ dose, type = 'discrete',
                           theta = 0.33, alpha = 0.25,
                           min_dose = 0, max_dose = 100,
                           dose_set = seq(0, 100, 20),
                           rho_prior = matrix(1, ncol = 2, nrow = 2),
                           rounding = "nearest")
stop_rule_d1extended(step_zero)
response_sim <- response_d1extended(rho = c(0.05, 0.95),
                                   min_dose = 10, max_dose = 50)
sim <- ewoc_simulation(step_zero = step_zero,
                       n_sim = 2, sample_size = 30,
                       alpha_strategy = "conditional",
                       response_sim = response_sim,
                       stop_rule_sim = stop_rule_d1extended,
                       ncores = 1)
## End(Not run)