stop_rule_d1ph function

Generating a stop rule function for EWOC proportional hazards model

stop_rule_d1ph(step)

Arguments

• step: an object from the class 'ewoc_d1ph'.

Returns

a logical character indicating if the trial should be stopped or not.

Details

The stop rule function is evaluated at each step of the trial. It can defined based on any information contained in the object 'step' that is the output from one of the functions 'ewoc_d1ph'.

Examples

## Not run:

time <- 9
status <- 0
dose <- 20
step_zero <- ewoc_d1ph(cbind(time, status) ~ dose, type = 'discrete',
                      theta = 0.33, alpha = 0.25, tau = 10,
                      min_dose = 20, max_dose = 100,
                      dose_set = seq(20, 100, 20),
                      rho_prior = matrix(1, ncol = 2, nrow = 1),
                      mtd_prior = matrix(1, ncol = 2, nrow = 1),
                      distribution = 'exponential',
                      rounding = 'nearest')
stop_rule_d1ph(step_zero)
response_sim <- response_d1ph(rho = 0.05, mtd = 20, theta = 0.33,
                             min_dose = 10, max_dose = 50,
                             tau = 10, distribution = "exponential")
sim <- ewoc_simulation(step_zero = step_zero,
                      n_sim = 2, sample_size = 30,
                      alpha_strategy = "conditional",
                      response_sim = response_sim,
                      stop_rule_sim = stop_rule_d1ph,
                      ncores = 1)
## End(Not run)