calc_sd_3cmt function

Calculate C(t) for a 3-compartment linear model

calc_sd_3cmt(t, dose, dur = NULL, tinf = NULL, ...)

calc_sd_3cmt_linear_bolus(t, dose, ...)

calc_sd_3cmt_linear_oral_1_lag(t, dose, ...)

calc_sd_3cmt_linear_infusion(t, dose, tinf, ...)

calc_sd_3cmt_linear_oral_0(t, dose, dur, ...)

calc_sd_3cmt_linear_oral_0_lag(t, dose, dur, ...)

calc_sd_3cmt_linear_oral_1(t, dose, ...)

Arguments

• t: Time after dose (h)
• dose: Dose
• dur: Duration of zero-order absorption (h)
• tinf: Duration of infusion (h)
• ...: Passed to calc_derived_3cpt()

Returns

Concentration of drug at requested time (t) after a single dose, given provided set of parameters and variables.

Functions

• calc_sd_3cmt_linear_bolus(): Calculate C(t) for a 3-compartment linear model after a single IV bolus dose
• calc_sd_3cmt_linear_oral_1_lag(): Calculate C(t) for a 3-compartment linear model after a single oral dose
• calc_sd_3cmt_linear_infusion(): Calculate C(t) for a 3-compartment linear model after a single IV infusion
• calc_sd_3cmt_linear_oral_0(): Calculate C(t) for a 3-compartment linear model after a single dose, with zero-order absorption
• calc_sd_3cmt_linear_oral_0_lag(): Calculate C(t) for a 3-compartment linear model after a single dose, with zero-order absorption and a lag time
• calc_sd_3cmt_linear_oral_1(): Calculate C(t) for a 3-compartment linear model after a single oral dose

Examples

Ct <- calc_sd_3cmt_linear_bolus(t = 11.75, CL = 3.5, V1 = 20, V2 = 500,
    V3 = 200, Q2 = 0.5, Q3 = 0.05, dose = 100)
Ct <- calc_sd_3cmt_linear_oral_1_lag(t = 11.75, CL = 3.5, V1 = 20, V2 = 500,
    V3 = 200, Q2 = 0.5, Q3 = 0.05, ka = 1, dose = 100, tlag = 1.5)
Ct <- calc_sd_3cmt_linear_infusion(t = 11.75, CL = 3.5, V1 = 20, V2 = 500,
    V3 = 200, Q2 = 0.5, Q3 = 0.05, dose = 100, tinf=1)
Ct <- calc_sd_3cmt_linear_oral_0(t = 11.75, CL = 3.5, V1 = 20, V2 = 500,
    V3 = 200, Q2 = 0.5, Q3 = 0.05, dur = 1, dose = 100)
Ct <- calc_sd_3cmt_linear_oral_0_lag(t = 11.75, CL = 3.5, V1 = 20, V2 = 500,
    V3 = 200, Q2 = 0.5, Q3 = 0.05, dur = 1, dose = 100, tlag=1.5)
Ct <- calc_sd_3cmt_linear_oral_1(t = 11.75, CL = 3.5, V1 = 20, V2 = 500,
    V3 = 200, Q2 = 0.5, Q3 = 0.05, ka = 1, dose = 100)

References

Bertrand J & Mentre F (2008). Mathematical Expressions of the Pharmacokinetic and Pharmacodynamic Models implemented in the Monolix software. http://lixoft.com/wp-content/uploads/2016/03/PKPDlibrary.pdf

Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications (4th). Lippincott Williams & Wilkins, Philadelphia, 2010.

Author(s)

Justin Wilkins, justin.wilkins@occams.com

Bill Denney, wdenney@humanpredictions.com