Pharmacometric and Pharmacokinetic Toolkit
A transform for ggplot2 with data that may be below the lower limit of...
Generate breaks for measurements below the limit of quantification
Calculate derived pharmacokinetic parameters for a 1-, 2-, or 3-compar...
Calculate C(t) for a 1-compartment linear model
Calculate C(t) for a 2-compartment linear model
Calculate C(t) for a 3-compartment linear model
Calculate C(t) for a 1-compartment linear model at steady-state
Calculate C(t) for a 2-compartment linear model at steady-state
Calculate C(t) for a 3-compartment linear model at steady-state
Count the number of NA values in a vector.
Generate a summary table of descriptive data for every individual in a...
Estimate the lower limit of quantification (LLOQ) from a vector
Format a number with the correct number of significant digits and trai...
Forward transformation for linear BLQ data
Calculate a geometric coefficient of variation.
Convert geometric variance or standard deviation to a geometric coeffi...
Calculate the area under the curve (AUC) for each subject over the tim...
Create a table of model parameter estimates from a NONMEM output objec...
Extract variability parameter estimates from a NONMEM output object.
Extract problem and estimation information from a NONMEM output object...
Extract shrinkage estimates from a NONMEM output object.
Extract residual variability parameter estimates from a NONMEM output ...
Extract structural model parameter estimates and associated informatio...
Calculate geometric mean
Inverse transformation for linear BLQ data
Label axes with censoring labels for BLQ
Calculate percentage coefficient of variation
Provide concentration-time curves.
Plot a distribution as a hybrid containing a halfeye, a boxplot and ji...
Plot NONMEM parameter estimation by iteration.
Visualize PsN SCM output.
Read NONMEM 7.2+ output into a list of lists.
Read all NONMEM files for a single NONMEM run.
Read (single or) multiple NONMEM tables from a single file
Read a standard NONMEM extension file
Read in the NONMEM variance-covariance matrix.
Read NONMEM output into a list.
Reads NONMEM output tables.
Read PsN SCM output into a format suitable for further use.
Read NONMEM 7.2+ output into an R object.
Sample from the multivariate normal distribution using the OMEGA varia...
Sample from the multivariate normal distribution using the SIGMA varia...
Sample from the multivariate normal distribution to generate new sets ...
Read NONMEM output into a list.
Pharmacometric tools for common data analytical tasks; closed-form solutions for calculating concentrations at given times after dosing based on compartmental PK models (1-compartment, 2-compartment and 3-compartment, covering infusions, zero- and first-order absorption, and lag times, after single doses and at steady state, per Bertrand & Mentre (2008) <http://lixoft.com/wp-content/uploads/2016/03/PKPDlibrary.pdf>); parametric simulation from NONMEM-generated parameter estimates and other output; and parsing, tabulating and plotting results generated by Perl-speaks-NONMEM (PsN).