pk_curve function

Provide concentration-time curves.

pk_curve(
  t,
  model = "1cmt_oral",
  params = list(ka = 2.77, CL = 2.5, V = 25),
  dose = 600,
  ii = 24,
  addl = 0,
  ss = F
)

Arguments

• t: Observation time in h, specified as a vector.
• model: The model to use. Must be one of "1cmt_bolus", "1cmt_infusion", "1cmt_oral", "2cmt_bolus", "2cmt_infusion", "2cmt_oral", "3cmt_bolus", "3cmt_infusion", "3cmt_oral". The default is "1cmt_oral".
• params: A named list containing parameter values for the selected model type.
• dose: Dose amount.
• ii: Interdose interval (or tau), in hours (default 24).
• addl: Number of additional doses (default 0).
• ss: Assume steady state concentration (default FALSE).

Returns

A data frame containing times (t) and concentrations (cp).

Examples

plot(pk_curve(t=seq(0,72,by=0.1), model="3cmt_oral", ii=12, addl=5,
  params=list(CL=2.5, V1=25, V2=2, V3=5, Q2=0.5, Q3=0.25, ka=1)), type="l")

Author(s)

Justin Wilkins, justin.wilkins@occams.com